CH610B Sophomore Organic II

Dr. Brian Pagenkopf   


 

 

Propose a synthesis of the following alcohol from an epoxide and a Grignard or Gilman reagent:

 

 

There can often be two ways to make the same alcohol.

 

 

Strategy A gives these pieces:

 

 

Strategy B gives these pieces:

 

For practice, work out a scheme similar as the one above for preparation of secondary alcohols from aldehydes.