NITED NATIONS, May 2 — The director of Brazil's AIDS program accused the Bush administration today of toughening America's stance toward Brazil's manufacture of generic AIDS drugs and of dragging AIDS policies into trade negotiations.

Dr. Paulo Roberto Teixeira, head of the Brazilian program on H.I.V.- AIDS and other sexually transmittable diseases, who is in New York to discuss plans for a special United Nations General Assembly session on AIDS in June, said that a report released Monday on patent protections issued by the United State Trade Representative was "unacceptable."

With the approach of the special session, Brazil is positioning itself to take the lead over South Africa and other affected countries in the debate over drug prices. Unlike South Africa, where officials delayed employing aggressive anti-AIDS programs for years, Brazil was among the first developing nations to deal with the epidemic on many fronts. Its program is considered a model for the third world.

Among the decisions Brazil made was to order the production of generic AIDS drugs to compete with higher-priced drugs from international pharmaceutical companies. American drug manufacturers charged patent violations. The Clinton administration did not press the issue.

At a news conference here today Dr. Teixeira said that the new criticism and the implied threat of trade action against Brazil "is a clear change in the attitude and the position of the American government."

The report from the United States trade representative, Robert B. Zoellick, said, "Certain countries try to justify the use of protectionist measures by associating these measures with the AIDS crisis when no such linkage exists."

Singling out Brazil, it said Brazil's government had chosen a broad application of its patent law, leaving open the possibility that the measure would also be applied to other goods not related to health.

Dr. Teixeira said Brazil was not in competition with American manufacturers of AIDS drugs and had no intention of exporting its AIDS drugs, which are for domestic use.

"They say that there are some good AIDS programs in the world and they exclude Brazil from that, and we know why," Dr. Teixeira said. He noted that Thailand, Senegal and Uganda did not insist on wide access to antiretroviral medicines.

"If at the global level or in talking about international relations, the U.S.T.R. will be in charge to say what is good and what is not good for AIDS prevention and control — saying even what kind of strategy will be adopted by countries — I think we are lost," he said.