URL: http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v409/n6820/full/409551b0_fs.html
Date accessed: 25 February 2001
Nature 409, 551 (2001) © Macmillan Publishers Ltd.
01 February 2001
DAVID DICKSON AND
DAVID CYRANOSKI
[LONDON TOKYO] Syngenta, the world's largest
agribusiness corporation, and gene-discovery company Myriad Genetics have
sequenced the complete rice genome. But the sequence will be available only
through contracts and will not be published. The genome is the second largest to have been sequenced to date (smaller only
than the human genome) and the first for a crop plant. The project took only 18
months and has produced a genome map that the companies say is "99.5%
complete". The publicly funded effort to sequence the rice genome's 430
million DNA bases, led by Japan, is three years away from completion. Myriad, which is based in Salt Lake City, says that its proprietary
high-throughput sequencing facilities enabled it to complete the genome six
months ahead of schedule — earning a $3 million bonus from Syngenta as part of
a $33 million deal. The companies' success has raised worries about the impact on poorer
countries that rely on rice as a staple food crop. But Syngenta says it will
provide information and technology that can produce crop improvements for
subsistence farm-related research "without royalties or technology
fees". The company says that it will make its rice genome data — derived from the
Nipponbare variety — available to researchers through "research
contracts". Given the apparent — and apparently unexpected — similarity between the
rice genome and those of various cereals, the rice sequence is expected to aid
the study of crops such as wheat, corn and barley. Syngenta's announcement has shaken partners in the publicly funded
International Rice Genome Sequencing Project (IRGSP), which has sequenced 5% of
the genome to completion and an additional 25% to the level of quality achieved
by Syngenta's sequence. Takuji Sasaki, principal investigator of the IRGSP, says the project's
partners will meet next week and discuss Syngenta's results. He says the claim
of 99.5% completeness will be difficult to verify "as the company won't
show its cards". But he worries that politicians may nonetheless consider
the job done and pull the plug on the publicly funded project. This would be
unwise, he says, as the IRGSP's sequence will be both more accurate than
Syngenta's and freely available.
Categories: 16. Economics and Biotechnology, 32. Genome Project and Genomics