The Canadian Trial of Physiologic Pacing Investigators,
a randomized controlled trial conducted in 2000, determined that
for the prevention of stroke and death due to cardiovascular causes
physiologic pacing (dual chamber AV sequential) provides little benefit over ventricular pacing.
P=0.26
However, the rate of atrial fibrillation was significantly lower
among patients in the physiologic pacing group.
P=0.0093
Graphs modified from Kerr CR, et al. Canadian Trial of Physiological
Pacing: Effects of physiological pacing during long-term follow-up.